Short-Cut Pathway to Synthesize Cellulose of Encysting Acanthamoeba

Short-Cut Pathway to Synthesize Cellulose of Encysting Acanthamoeba

The mature cyst of Acanthamoeba is highly resistant to various antibiotics and therapeutic agents. Cyst wall of Acanthamoeba are composed of cellulose, acid-resistant proteins, lipids, and unidentified materials. Because cellulose is one of the primary components of the inner cyst wall, cellulose synthesis is essential to the process of cyst formation in Acanthamoeba. In this study, we hypothes...

Identification of Atg8 Isoform in Encysting Acanthamoeba

Autophagy-related protein 8 (Atg8) is an essential component of autophagy formation and encystment of cyst-forming parasites, and some protozoa, such as, Acanthamoeba, Entamoeba, and Dictyostelium, have been reported to possess a type of Atg8. In this study, an isoform of Atg8 was identified and characterized in Acanthamoeba castellanii (AcAtg8b). AcAtg8b protein was found to encode 132 amino a...

Chloroquine has cytotoxic effect in encysting Acanthamoeba through 1 modulation of autophagy

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This article reviewed recent studies investigating the risk of developing inflammatory bowel disease (IBD)-associated CRC, a major potential complication of IBD. In patients with ulcerative colitis (UC) the risk of CRC increases with a younger age of diagnosis (age 0-19 years), longerdisease duration and concomitant primary sclerosing cholangitis. Of note, an underlying genetic predisposition i...

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This Iranian team collected data of newly diagnosed cancer cases in the Golestan province of Iran in a 5 year period from 2004 to 2008. This area previously had one of the highest oesophageal cancer rates in the world. 9007 new cancer cases were reported from 68 healthcare centres in the province and the death registry. 71% of cases had microscopic verification. Incidences were reported as age-...